Prior to USP 800 , third party testing of wipe/swab samples revealed contamination problems both inside the lab and, more troubling, in general areas like break rooms and retail space. Similar results found in compounding pharmacies throughout the USA. To prevent that, USP 800 has as requirement negative pressure rooms in order to eliminate the problems associated with air exchanges between compounding pharmacy labs and adjoining areas. Most compounding labs are positive pressure environments, meaning, pressure differentials can cause air exchanges which carry airborne particles of hazardous drugs outside of the lab, to areas such as break rooms and retail spaces. In the extreme case of an accidental chemical spill, millions of particles are airborne and have a more real potential for exchange and exposure in common areas. Additionally, HVAC systems circulate air through pharmacy labs and common spaces, but the lack of filtration system fails to produce clean room air exchanges. HVAC systems were not designed for the purpose of hazardous drug handling.Odulair provides a negative pressure ISO 7 room with tight tolerance for hazardous drug compounding and storage.